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Muscle recovery: Functional gait improvements in crush injury models, with histological evidence of reduced fibrosis and increased muscle fiber regeneration (Novinscak et al., 2008)

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Although cardiovascular risk has not been elevated in short-term trials, comprehensive long-term data are still pending

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Conversely, inhibiting NNMT allows existing NAD+ (or NAD+ from moderate precursor supplementation) to accumulate, potentially restoring NAD+-dependent pathways more effectively than precursor supplementation alone