There are no documented organ toxicity signals in the published literature
Through co-immunoprecipitation (CO-IP) experiments, we discovered that FOXO4-DRI prevents the binding of FOXO4 to P53, facilitating the phosphorylated P53 nuclear exclusion, which subsequently trigger BAX and cleaved caspase-3, leading to the apoptosis of senescent cells
In animal models , it has demonstrated enhanced wound healing and regenerative activity
Alqahtani Y, Wang S, Najmi A, Huang Y, Guan X
Clinical findings of a palliative care consultation team at a comprehensive cancer center
Importantly, many of these adverse effects were derived from self-reported experiences of the participants, which introduces variability in both perception and reporting accuracy