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In certain embodiments, the preparations optionally contain a suitable buffering system, such as phosphate, citrate, borate, tris, etc., and pH regulators such as sodium hydroxide and hydrochloric acid also are optionally used in the formulations of the disclosures

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Sodium Methyl Cocoyl Taurate / Cocamidopropyl Betaine / Sodium Lauroamphoacetate / Potassium Cocoyl Glycinate / Sodium Lauroyl Sarcosinate: These are gentle cleansing agents that remove debris without causing the inflammation associated with harsher sulfates

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The use of methotrexate may additionally invalidate diagnostic assays for folic acid and vitamin B12

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