They found that even without causing weight loss, retatrutide had anti-tumor effects that were similar to the currently used (and incredibly expensive) immunotherapy.[ref] A 5-year mortality study in colon cancer patients showed that GLP-1 RA use decreased mortality risk by 60% in obese patients.[ref] Animal studies may show the mechanism
Step 3: Handle Gently
Although semaglutide (Ozempic/Wegovy) has largely overtaken liraglutide in clinical preference due to its weekly dosing and greater weight loss efficacy, liraglutide retains several advantages: it has over 15 years of post-marketing safety data, cardiovascular outcome data from the landmark LEADER trial, and pediatric approvals for both diabetes and obesity
How to Microdose Semaglutide and Tirzepatide: The Importance of Clinical Oversight If youre wondering how to microdose GLP-1 medications safely, its critical to understand that professional medical supervision is essential
Retatrutide Phase 3 data is still emerging, and the TRIUMPH-4 population specifically had knee osteoarthritis, which may influence adherence and outcomes
What is the FDA-approved use of O zempic