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4 Microbiome dependence and causal evidence: graded verification system (A-level +/A/B) 4.1 Level A + studies: closed-loop evidence + mechanistic pathway intervention (ABX FMT rescue/in vivo blocking + in vitro blocking) 4.1.1 Fengshining decoction (FSN) ABX (Low-Biomass Background/Modeling Foundation): This study established a strict low-microbial baseline by taking four antibiotic mixtures continuously for 14 days before modeling, and confirmed a significant decrease in the diversity and number of microorganisms through 16S sequencing verification ( FMT (Transferability Test): After antibiotic treatment, three groups were established: FSN donor fecal bacteria transplantation group, model donor fecal bacteria transplantation group and antibiotic control group, and FSN intervention was carried out at the same time (daily gastric irrigation for 21 days)

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When comparing the two types of HF, patients with HFrEF had a greater likelihood of experiencing bleeding complications and dialysis dependency post-surgery, while those with HFpEF were more susceptible to pulmonary edema and cardiac arrest events [66]