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Metoclopramide has traditionally been a first-line prokinetic therapy, but this agent should be administered at the lowest effective dose and for limited periods of time due to the real risk of adverse effects

What it means: Thermoregulatory nerve fibers are affected

Retatrutide is looking like it might be the most effective weight-loss drug yet, showing greater percentage decreases in total body weight when compared with not only other GLP-1 therapies but even some surgical procedures

S., Arnold, K., Mackenzie, C., et al

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Conversely, if GLP-1-related blunting is selective to reward-related content, these compounds may normalize aberrant hyperreactivity in individuals with obesity or substance use disorders without reducing negative affective processing