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Physiology, Proteins

Endonuclease G is an apoptotic DNase when released from mitochondria

This is often accompanied by increased sebum production as the skin attempts to protect itself from environmental aggressors

This specific property has become the focus of numerous research strategies, such as the development of senolytic agents like FOXO4-DRI, which selectively disrupt the FOXO4p53 interaction, thereby enabling the targeted elimination of dysfunctional cells