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The initiation phase involves the generation of ROS, including free radicals like hydroxyl radicals (OH), superoxide anions (O 2 ), and non-radical oxidants like hydrogen peroxide (H 2 O 2 ) [48, 49]

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evidence published after the priority date of the patent), including BBC reports in which experts described semaglutide as a game a changer in obesity treatment, and clinical trial data

Carlson BA, Tobe R, Yefremova E, Tsuji PA, Hoffmann VJ, Schweizer U, et al

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During clinical trials, adults taking Wegovy lost as much as 15% of their total body weight