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Reports have surfaced of nervous system problems, and since there are no consistent quality standards for these treatments, the risks are unpredictable

The curcumin and gallic acid -loaded microneedles provide immediate antioxidant and anti-inflammatory effects, alleviating AD symptoms in the short term, while the embedded PLGA needle mediates the sustained release of curcumin for long-term improvement

Change history 28 May 2026 A Correction to this paper has been published: References Woodby B, Penta K, Pecorelli A, Lila MA, Valacchi G

The bioregulator peptide approach of modulating existing biological pathways rather than forcing artificial responses distinguishes PTD-DBM from many conventional treatments