Dilated fundus evaluation demonstrated notable optic disc edema, mostly concentrated superiorly/superonasally in the right eye (Figure 5)
However, big pharma will still have the ability to charge premium prices for innovator molecules, especially those with higher efficacy (eg retatrutide) and those aimed at niche patient populations rather than the mass market (eg survodutide, which is targeting MASH endpoints in clinical trials)
While the specific mechanism causing the effects on the gastrointestinal tract are not fully elucidated, studies suggest GLP-1 and its analogues likely exert effects on the vagus nerve and inhibit cholinergic neurotransmission in the gastrointestinal system to prevent movement of the intestine
the curative effect is moderate and suboptimal in the long term (12)
The medical takeaway is simple: retatrutide is not just another celebrity weight-loss trend. It is part of a larger movement toward more powerful incretin-based therapies that may change how obesity, metabolic disease, and body composition are treated
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