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What Each Compound Does Retatrutide (LY3437943) is a triple agonist: GLP-1 (cuts appetite, slows the stomach), GIP (improves insulin signaling), and glucagon (raises energy use and fat burning)

doi: 10.3390/ijms23031105 70 Del Toro-BarbosaMHurtado-RomeroAGarcia-AmezquitaLEGarca-CayuelaT

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However, a high proportion of people with T2D discontinued GLP-1 RA treatments despite a low proportion of people with GI AEs

Cilia R, Akpalu A, Sarfo FS, Cham M, Amboni M, Cereda E, Fabbri M, Adjei P, Akassi J, Bonetti A, Pezzoli G (2014) The modern pre-levodopa era of Parkinsons disease: insights into motor complications from sub-Saharan Africa