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In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression

There are no documented serious adverse effects from taking excess vitamin B12

Most individuals can benefit safely, but pregnant or breastfeeding women, people with known vitamin or nutrient sensitivities, or those with specific medical conditions should consult with a healthcare provider before receiving injections

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In addition to the cost of the injections themselves, there may be fees for the administration of the shot, especially if done at a healthcare facility

CD38 is an ectoenzyme (NADase) whose expression increases with age and chronic inflammation