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High levels of estrogen sulfate can be a risk factor for breast cancer

Abstract Oxidative stress (OS) is established as a key factor in the etiology of both male and female infertility, arising from an imbalance between reactive oxygen species (ROS) production and the endogenous antioxidant (AOX) defenses

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reported elevated IGF-1 expression at day 5 in a rabbit supraspinatus tendon healing model ( Although the timing of IGF-1 upregulation varies across studies, likely due to differences in species, experimental methods, and tendon locations, the consensus is that IGF-1 expression is significantly elevated during tendon healing