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In support of this notion, normalization of SR calcium handling in animal models of heart failure (HF) has been shown to reduce the incidence of cardiac alternans and ventricular arrhythmias [25]

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diarrhea is typically secondary to conditions causing malabsorption (e.g., IBD, celiac) rather than B12 itself

18 Because of the association between pernicious anemia and a higher incidence of gastric cancer and carcinoids, it is important to pursue a diagnosis and, if confirmed, recommend endoscopy

This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Stockwell et al., 2017

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