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Hoboken, NJ, USA: John Wiley & Sons, Inc., 2018, p

larger trials are underway to confirm long-term efficacy

Because of their glucose lowering effects, therapies that enhance incretin actions through inhibiting degradation of endogenous incretins or through activation of the GLP-1 receptor are now in use for the treatment of type 2 diabetes

Starting at a high dose significantly increases nausea, vomiting, and gastrointestinal side effects without improving weight loss outcomes compared to gradual titration

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Carlson MG, Peterson CG, Venge P: Human eosinophil peroxidase: purification and characterization