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[3] At its core, GLP-1 works by enhancing your body's natural hunger-regulating system, making it easier to eat less, feel fuller, and make healthier choices effortlessly

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GLP-1R signaling in the spinal cord has been suggested to account for the mild tachycardia caused by GLP-1R agonists, and may also be involved in the therapeutic effects of these drugs

More recently, a long-acting exendin-4-based analog bound to the Fc portion of immunoglobulin G (IgG) known as efpeglenatide is under clinical development, and would also be suitable for a once-weekly injection [8,9]

Insulin glargine injection has received marketing authorization from the European Commission (EC), while for insulin lispro injection and insulin aspart injection, it has received the positive opinion from CHMP of EMA

Figure 4A