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You see that their tirzepatide dose was increased

Risks associated with obesity are primarily related to metabolic disorders, which contribute to the development of Type 2 diabetes mellitus and other diseases including osteoarthritis and sleep apnoea

[1] A separate trial showed tirzepatide produced even greater average weight loss across dose levels

While the differences are not enormous, they are consistent across doses, and they become more meaningful at higher weight loss thresholds where muscle preservation becomes increasingly challenging

doi: 10.1007/s00018-011-0905-1

f , Heatmaps of preDRB-nRNA-seq data from the TSS into the first 60 kb of active genes larger than 60 kb in control and INTS12 KO cells, followed by the indicated times