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Published in the New England Journal of Medicine , this latest pharma-sponsored study focuses on liraglutide, the active ingredient in the drug sold as Saxenda

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doi: 10.2337/db06-1491 129 BrayJJHFosterDaviesHSalemAHooleALObaidDRHalcoxJPJet al

Some of the research, including this 2025 review, indicates that it may reduce headache frequency, severity, and intensity, but again, more research is needed to confirm the appropriate dosage