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[1] This process contributes to weight loss, especially when paired with lifestyle changes like diet and exercise

Frias JP, Nauck MA, Van J, Kutner ME, Cui X, Benson C, et al

Prescription GLP-1 receptor agonists produce sustained, supraphysiologic levels of GLP-1 activityfar exceeding what dietary modifications can achieve

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Key findings for semaglutide duration include continued weight loss through at least 68 weeks with no plateau in many patients, weight regain of approximately 40% of lost weight within seven months of stopping, and withdrawal effects including increased appetite, food cravings, and in some cases gastrointestinal changes