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Tier 2 and Tier 3 weight management services provide intensive support Dietetic input : Specialist dietitians can develop individualised plans accommodating Crohn's-related dietary restrictions whilst achieving caloric deficit Psychological support : Cognitive behavioural therapy and motivational interviewing address eating behaviours and emotional factors Physical activity programmes : Tailored exercise plans considering Crohn's-related fatigue and extra-intestinal manifestations Bariatric surgery represents the most effective long-term weight management intervention for severe obesity

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There hasnt yet been a direct head-to-head study comparing the two drugs, and cross-trial comparisons are inconclusive

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Without sufficient protein, patients risk losing substantial muscle mass alongside fat tissue, which can reduce metabolic rate, impair physical function, and compromise long-term weight maintenance