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The N-terminal thioredoxin domain is often described as two distinct motifs: an N-terminal motif (112) and a C-terminal motif (343) linked by helix 2 and which together form a four -sheet in the order 2134 with 3 anti-parallel to the others (Figure 5A)

By 1997, Ng and colleagues had identified the C-terminal segment of human GH as the primary region governing fat metabolism, and created AOD 9604 by adding a tyrosine residue to the fragment to enhance its stability

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(2018) Int J Mol Sci

Additionally, as an antioxidant, glutathione reduces oxidative stress in the skin, which is relevant because oxidative stress (from UV sun exposure or inflammation) can stimulate more melanin production