The authors would like to acknowledge the research team in the Department of Tissue Engineering and Regenerative Medicine (DTERM), Faculty of Medicine, Universiti Kebangsaan Malaysia, for the technical support throughout this review
Symptoms often only appear once IDA has developed
Gastroenterology 102 , 330354 (1992)
In addition, oxidative stress-induced cytochrome c (Cyt c) release from mitochondria, by changing the mitochondrial membrane potential, activates the apoptosis cascade (Redza-Dutordoir and Averill-Bates, 2016)
This change to the structure extends the half-life to about 170 to 180 hours, which allows for dosing once a week
Cell Mol Neurobiol 43:27432759 Andrasson M, Brodin L, Laffita-Mesa JM, Svenningsson P (2017) Correlations between methionine cycle metabolism, COMT genotype, and polyneuropathy in L-dopa treated Parkinsons disease: a preliminary cross-sectional study