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In summary, Vitamin B12 itself does not cause weight gain
Wang Y, Wan C, Szoke G, Ryaby JT, Li G
The deficiency can arise due to improper diet or the inability to absorb the vitamin through natural means
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Last, addition of the TCA cycle intermediate -ketoglutarate to the Rb TKO MEFs reversed the inhibitory effects of glutamine deprivation on ATP, GSH levels and viability