GLP-1 RAs, such as semaglutide and tirzepatide, may also help improve metabolic health in patients with PCOS by promoting weight loss, improving insulin sensitivity, and reducing blood glucose levels ( 4 , 6 , 14 )
Iacovelli, J
Choline is an essential nutrient which is absorbed in the upper small intestine by specific enterocyte transporters via facilitated (Radziejewska and Chmurzynska, 2019), only excessive amounts are metabolized into TMA by the gut microbiota in the colon (Papandreou et al., 2020)
Given the direct GI effects of these drugs, together with the potential GI side effects of vomiting and diarrhoea, all of which could affect oral contraceptive absorption, the FSRH guidance is both welcome and reassuring
Cyanocobalamin (B12) 1000 mcg with sodium chloride 0.8% w/v and benzyl alcohol 1.5% v/v (preservative)
Targeting populations with unmet medical needs presents a significant opportunity for successful drug launches