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In animals, SGLT2 inhibitors cause dilatation of the renal pelvis and tubules of the kidney when used during the second and third trimester and additionally a relatively large number of unfavorable human pregnancy outcomes are found in humans

This doesn't mean extra is good, so dont exceed more than the recommended guidelines

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[4] [5] [6] [7] These medicines are prescribed because the expected health benefits can be significant

Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet