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Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

Cells were prepared and stained as per the Leica protocol ( In brief, cells were plated onto coverslips and treated with or without 5FU at the indicated doses for 72 h

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To obtain the specific labeling patterns, intracellular metabolites were extracted and analyzed using GC/MS to determine multiple ion detections (MIDs) (corrected for natural isotope abundance), which reflect relative metabolic fluxes 28

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[8] PONZO, V