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These compounds increase SIRT1 expression or activity, collectively improving hepatic lipid metabolism, insulin signaling, oxidative stress, autophagy, and inflammatory responses, highlighting their strong multi-target pharmacological potential

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10.1111/j.1365-2362.2006.01618.x Hoensch H, Morgenstern I, Petereit G, Siepmann M, Peters WHM, Roelofs HMJ, Kirch W: Influence of clinical factors, diet, and drugs on the human upper gastrointestinal glutathione system

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The atomic coordinates and electron microscopy maps have been deposited in the Protein Data Bank (PDB) under accession codes: 7DUR (compound 2GLP1RG s complex), 7DUQ (compound 2GLP-1-GLP-1RG s complex) and 7E14 (compound 2LY3502970GLP-1RG s complex) and Electron Microscopy Data Bank (EMDB) accession codes: EMD-30867 (compound 2GLP1R-G s complex), EMD-30886 (compound 2GLP-1GLP-1RG s complex) and EMD-30936 (compound 2-LY3502970GLP-1RG s complex), respectively