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Animal studies and a small intravenous healthy-volunteer study established GH-release pharmacology

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Clinical trials show about 40% to 45% of people on tirzepatide experience nausea at higher doses compared to 30% to 40% with semaglutide

Preliminary real-world data suggests that these medications may reduce progression to chronic kidney disease, potentially by inhibiting the NF-kB inflammatory pathway that drives renal damage