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Journal of Clinical Oncology 41(12):2181-2190, 2023

Bernthal NM, Putnam A, Jones KB, Viskochil D, Randall RL

Rapid Weight Loss and Metabolic Changes Significant metabolic changes during rapid weight loss may temporarily affect the cardiovascular system while the body adjusts to: Reduced calorie intake Hormonal changes Fluid shifts Appetite suppression Medication Interactions Patients taking blood pressure medication may experience changes as weight loss improves cardiovascular health

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As a proof of concept, we chose to include the potent PPAR agonist WY14643 58,59,60,61 during stage 6 of the differentiation program given our observations of a relative lack of PPAR target gene expression throughout the SC- cell maturation trajectory despite a maintenance of PPAR motif activity (Figs