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Resveratrol mediates the miR-149/HMGB1 axis and regulates the ferroptosis pathway to protect myocardium in endotoxemia mice

doi: [Elsevier] Ajith TA, Ranimenon

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A decrease in oxygen supply, resulting in hypoxia is also strongly connected with breakdown of the BBB, resulting in increased oxidative stress and permeability

While DSIP was described as 'adaptogenic' and stress-protective in older animal work, robust human data demonstrating a cortisol-lowering effect are lacking, and claims of a defined anti-stress action should be treated cautiously

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