Sparse clinical evidence versus real-world experience In a review of the evidence posted ahead of the meeting, they repeatedly note the data comes primarily from preclinical work involving animals and is quite limited for humans
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After reaching target organs through blood circulation, the iron bound TF then binds up to the transferrin receptor 1 (TFR1) and is internalized under the clathrin-dependent endocytosis
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doi: 10.3389/fmed.2026.1752341 Received 23 November 2025 Revised 04 April 2026 Accepted 10 April 2026 Published 29 April 2026 Volume 13 - 2026 Edited by Wei Liu, Huazhong University of Science and Technology, China Reviewed by Jheng-Yan Wu, Chi Mei Medical Center, Taiwan Jennifer Teske, University of Arizona, United States Updates Copyright 2026 Fang, Zhu, Rao and Liu