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Its commonly stated that the upper arm is harder to self-inject

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The medication enters your bloodstream through these membranes directly, bypassing the digestive system entirely

The GLP-1-activated neurons in the brain also limit appetite for a while after a large meal (e.g., the thought of eating is unappealing for many hours after pigging out on pizza).[ref] Stress-related appetite suppression: Additionally, the GLP-1 neurons activate during times of acute stress to suppress appetite

That is roughly 40-50% more weight loss from the triple receptor approach

Age, AUDIT-C score, body mass index (BMI), and sex were also included in the models