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In guinea pigs fed a high-cholesterol diet, lutein (0.1 g per 100 g) therapy prevents degenerative diseases in the liver by lowering hepatic free cholesterol, lipid peroxidation, and attenuating the inflammatory responses known to be involved in the development of non-alcoholic fatty liver disease (NAFLD) [74]

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The results revealed a decrease in androgen receptor expression in both epithelial and stromal cells following 3 months of metformin treatment, while HOXA10 expression increased in stromal cells

The conversion into insulin occurs after the removal of the c-peptide in the Golgi apparatus, with a final maturation achieved by c-terminal amino acid elimination (Steiner, 2004)