Compounded versions often include additives like vitamin B6 or other peptides, and dosing may differ from the branded equivalents
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Some patients, particularly those with long-standing diabetes, may develop impaired awareness of hypoglycaemia , where warning symptoms are diminished or absent, increasing the risk of severe episodes
Eli Lilly's tirzepatide (Mounjaro/Zepbound), a dual GIP/GLP-1 receptor agonist, has demonstrated superior weight loss outcomes (approximately 22.5% mean weight reduction in SURMOUNT-1 versus 14.9% for semaglutide), and its accelerating market penetration in the United States is beginning to exert competitive pressure on semaglutide's market share in the weight management segment
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