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More recently, a causal relationship between IFN-, endoplasmic reticulum (ER) stress, and HLA-I upregulation has been demonstrated in -cells 2,13

Future research should bridge the gap between nutritional neuroscience and clinical evidence, optimize overall dietary patterns, and investigate the mechanisms by which nutrients interact with the gut microbiota and central nervous systemultimately improving and preventing mental health through dietary interventions

GIP agonism: Co-activation of glucose-dependent insulinotropic polypeptide receptors (as in tirzepatide) enhances insulin sensitivity, reduces inflammation in adipose tissue, and may mitigate some GLP-1-mediated nausea through CNS pathways

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Collagen peptides have some evidence for modest improvement in knee pain and function in mild osteoarthritis