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Intratumoral heterogeneity is a hallmark of the disease, showing multiple driving mutations within a single tumor (6) which is reflected in morphological, transcriptional, genetic, epigenetic, functional diversity

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doi: 10.1186/1472-6882-10-1 116 KangYCaiYZhangXKongXSuJ

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Given that the primary mechanism underlying liver fibrosis is linked to the activation of stellate cells, this microneedle technology stands out for its ability to safeguard liver cells and potently curb the initiation and advancement of fibrosis [180]