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PMC 6461196

The semaglutide versus tirzepatide comparison provides the most detailed side-by-side analysis available

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Mougeot, J

They work by imitating glucagon-like peptide-1 (GLP-1), a growth hormone that triggers insulin release, reduces blood sugar levels, slows the passage of food along the intestinal tract and stimulates parts of the brain that control craving and satiety

In addition, the redox imbalance in the cells of the alveolar epithelium, their apoptosis, the increase in inflammation and, consequently, the alteration of gas exchange, also cause a local increase in angiotensin II levels after the inactivation of the ACE2 receptor by the SARS-CoV-2