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Both receptors belong to the class B G-protein-coupled receptor (GPCR) family, and their co-activation produces a distinct downstream signalling profile that sets tirzepatide apart from single-receptor agonists such as semaglutide

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It is designed to support long term success when combined with proper nutrition, physical activity, and lifestyle changes

J.BenfeitoS.SilvaV.ChavarriaD.BorgesF.et al (2023)