After two months of this cycle, he developed what he calls zombie modetoo tired to exercise but too wired to rest
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Maintaining weight loss remains a challenge with GLP-1 drugs, as many patients experience weight regain once the treatment is discontinued or after prolonged use
In Phase II clinical trials in adults with overweight or obesity, once-daily orforglipron led to 9-15% mean weight loss at 36 weeks, with a GI tolerability profile typical of the class
I think this is a really important signal, and it may reflect that these patients were able to optimize their metabolic health prior to conception, Dr
Appetite Regulation and Behavior Change Many patients report a reduced desire to eat