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Lower fasting insulin and C-peptide Reduced HOMA2-IR (insulin resistance) Improved lipid profile (triglycerides) Raised adiponectin, lowered leptin Better glucose control Liver Fat Retatrutide reduced liver fat content by as much as 76% for MASLD patients, with the majority of the change occurring during the first 24 weeks

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doi: 10.1007/s11126-022-09998-z 25 Fernndez-de-Las-PeasCGmez-MayordomoVde-la-Llave-RincnAIPalacios-CeaMRodrguez-JimnezJFlorencioLLet al

While this is often seen as a positive effect, for some people, it can feel like jitteriness or anxiety