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Developed by Theratechnologies Inc., it underwent phase II trials in the mid-2000s for GH deficiency (GHD) and HIV lipodystrophy but was discontinued, with reported reasons including hypersensitivity reactions, including an anaphylaxis-like reaction in one trial participant Wong et al (2008) [Note: Abstract only

This applies even if you have previously used another GLP-1 medication, such as Mounjaro or Liraglutide

If a pen has been frozen, do not use it

A better way to think about berberine is that it may be a complementary metabolic support tool for some people, not a drop-in replacement for semaglutide

It is a custom preparation made by licensed compounding pharmacies that combine these two ingredients based on a prescriber order

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