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The low oxygen tension that characterizes this tissue may be an important component of the self-defense mechanism from free radical-mediated damage during spermatogenesis and Leydig cell steroidogenesis (3)

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Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig

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Environ Toxicol Pharmacol 85:e103634