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On the other hand, another pro-inflammatory cytokine is IL-8, which has numerous activities such as the migration of neutrophils, monocytes, tumor cell proliferation, and metastasis [32, 39]
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Although immune cells, such as CD8+ T cells, can recognize mutant antigens expressed on cancer cells and keep them in a dormant state 60 , chronic inflammation can reactivate dormant cancer cells via the EMT process and seed them onto new metastatic sites 61
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