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These agents provide multiple benefits, including weight reduction, cardio-renal protection, improved heart failure symptoms and hepatic steatohepatitis, and overall reduced mortality [2,3,4,5,6,7,8,9]

These findings were confirmed in humans by assessment of lactate concentrations in jejunal biopsies incubated with and without metformin [13]

People need supplements if their diet does not provide enough B vitamins, during hemodialysis, and for other reasons

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For the analyses of this estimand, missing values (unobserved due to patient loss to follow-up or other reasons) were assumed to be missing at random and were handled by multiple imputation using observed data in the placebo group