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In the RAW264.7 rodent macrophage cell line, dopamine only affected nitric oxide (NO) production at a concentration of 5 10 6 M, while much lower concentrations of the adrenergic receptor agonists norepinephrine and epinephrine increased lipopolysaccharide (LPS)-induced NO production, suggesting that dopamine may act through adrenergic receptors in this system (Chi et al., 2003)

doi:10.1016/j.freeradbiomed.2013.05.001 4

CNS delivery via adsorptive transcytosis

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Research has elucidated that patients with PF can exhibit elevated expression of TGF- in their fibroblasts and airway epithelium (Xu et al., 2016)