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Key Takeaways Starting dose: 2 mg once weekly for 4 weeks Titration pace: Increase every 4 weeks: 2 4 8 12 mg Maximum dose: 12 mg weekly (Phase 2/3 clinical trial protocol) Total ramp-up: ~16 weeks to reach maximum dose Mechanism: Triple agonist (GLP-1 + GIP + Glucagon), the only triple-agonist in late-stage trials Weight loss: Up to 24.2% at 48 weeks (Phase 2) and 28.7% at 68 weeks (Phase 3 TRIUMPH-4) GLP-3 Retatrutide Dosage Chart Free printable reference chart showing the retatrutide (GLP-3) clinical trial titration schedule from 2 mg to 12 mg weekly
Every "GLP-1 patch" sold online in 2026 is a dietary supplement sticker
Marketed in the 1950s as a treatment for morning sickness, it caused thousands of birth defects before its withdrawalbecoming a symbol of regulatory failure
The problem is not the concept of telemedicine, because reaching more women using modern technology can be a good thing, Its just that it isnt possible for someone providing quality telemedicine to be valued at $1B by simply being marginally more efficient than all the other Telehealth companies simply based on appointments and what most people would consider regular telemedicine care
This is why the over promotion of MHT and GLP-1s, as if they are something every woman should take, is indirectly beneficial to companies like MIDI, because the more people want MHT and GLP-1, the more opportunities to get subscribers for supplements, compounded hormones, and compounded GLP-1s
However, researchers have compared the impact of both drugs from different studies (this is called an indirect analysis) and suggested that the higher doses (10mg and 15mg) of tirzepatide might reduce HbA1c by 0.36% more than 2mg of semaglutide
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