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Sustainable Eating Patterns That Support Long-Term Weight Loss Crash diets and extreme calorie restriction backfire because they trigger metabolic adaptation and psychological deprivation, making long-term adherence impossible

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Soluble fibre is particularly effective: gut bacteria ferment it into short-chain fatty acids (SCFAs) like butyrate and propionate, which directly stimulate GLP-1-producing cells in the colon

However, the relevance of these findings to humans remains uncertain because human thyroid C-cells express GLP-1 receptors at much lower levels than rodent C-cells, suggesting potentially different susceptibility to GLP-1-mediated effects

In addition to GLP-1 RA medications

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