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A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide

It is mainly found in indigenous to Europe, western Asia, and North America

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(e.g., RTW, Atlas, Bain Capital Life Sciences) Biotech VCs determine what GLP-1 era 2.0 looks like, and founders should watch them closely because they create long-term infrastructure needs

P., Morillas-Arques, P., Molina-Barea, R., Rodriguez-Lopez, C