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This is a well-characterized physiological response to caloric deficit and weight loss, not a drug-specific anomaly

Report any signs of allergic reaction, since serious reactions have been reported with injected vitamin B12

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(Retatrutide Phase 2 pharmacokinetics) Rosenstock J, et al

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124 Bruijn, J., Duivenvoorden, H., Passchier, J., Locher, H., Dijkstra, N