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The four-week intervals are not just about GI tolerance

This delivery system significantly improved mucosal integrity, promoted vasodilation and glandular development, and reduced inflammatory cell infiltration in colonic tissues

doi: 10.1210/er.2009-0013 42 ItoKYamamuraSEssilfie-QuayeSCosioBItoMBarnesPJet al

10.1182/blood-2007-08-110098 Blood 5 AtagaK

Providers should verify injection technique, frequency, and whether appetite suppression is actually occurring at the prescribed dose before pursuing alternatives

Currently, three Phase III trials are in progress, designed to assess the comparative efficacy of a combination therapy consisting of arhalofenate plus febuxostat 40 mg versus febuxostat monotherapy at 80 mg